M.S. Ramaiah College of Arts, Science and Commerce (Autonomous) is housed in a modern, purpose-built academic campus designed to support quality education, research, and holistic student development. The institution operates from a flat-type, multi-storeyed academic building constructed in 2017, with a total built-up area of approximately 3,07,317 sq. ft., spread across six floors and three basement levels on a 2.9-acre campus.

The campus comprises 69 ICT-enabled classrooms, 30 well-equipped laboratories, faculty rooms, administrative offices, seminar halls, conference halls, meeting rooms, and state-of-the-art auditoria with advanced audio-visual facilities. The building is thoughtfully designed with wide corridors, ample natural lighting, proper ventilation, elevators, ramps, staircases, restrooms on every floor, and basement parking, ensuring safety, accessibility, and comfort.

The college is supported by a robust digital and learning infrastructure, including high-speed internet connectivity and campus-wide Wi-Fi, enabling technology-enabled teaching, blended learning, and access to digital academic resources. A fully automated Library and Information Centre with extensive print and electronic resources supports academic and research activities. The campus also integrates sustainable practices such as landscaped green spaces including medicinal and conservation-priority species, eco-friendly surroundings, and continuous infrastructure upgradation to meet evolving academic and technological needs. Additional amenities include a hygienic centralized cafeteria as per FSSI regulations, reprographic centre, nearby hostel accommodation for outstation students, medical support, and comprehensive CCTV surveillance to ensure campus safety.