• Qualification : M.Sc, PhD., CSIR-NET,GATE
  • Department : Department of Chemistry / Biochemistry
  • Designation : Assistant Professor
  • Experience : 8 years (Teaching), 8 Years (Academic Research)
  • Email ID:  sparkleshruthin@gmail.com

Academic / Professional Achievements

  • 2011    -    Recipient of scholarship from Vision Group of Science and Technology, Government of Karnataka, INDIA
  • 2011    -     Qualified Joint CSIR-UGC NET (All in India Rank 69), INDIA
  • 2012    -     CSIR-Junior Research Fellowship, INDIA
  • 2014     -    CSIR-Senior Research Fellowship, INDIA
  • 2015      -    Qualified GATE in Chemical Science, INDIA
  • 2016      -    NTU Research Scholarship, SINGAPORE
  • 2016      -     Receipt of Fellowship to Pursue PhD at University of Heidelberg, GERMANY (declined)


  •  Lixia Y.; Toh, D. -F. K.; Krishna, M. S.; Zhensheng, Z.; Yivao, L.; Shaomeng, W.; Yubin, G.; Chen, G. Tertiary Base Triple Formation in SRV-1 Frameshifting Pseudoknot         Stabilizes Secondary Structure Components. Biochemistry2020, Accepted (in press).

2.     Krishna, M. S.; Wang, Z.; Zheng, L.; Bowry, J.; Ong, A. A. L.; Mu, Y.; Prabakaran, M.; Chen, G. Incorporating G-C pair-recognizing guanidinium into PNAs for sequence and structure specific recognition of dsRNAs over dsDNAs and ssRNAs. Biochemistry2019, 58, 3777-3788.

3.     Krishna, M. S.; Toh, D. -F. K.; Meng, Z.; Ong, A. A. L.; Wang, Z.; Lu, Y.; Xia, K.; Prabakaran, M.; Chen, G. Sequence- and structure-specific probing of RNAs by short nucleobase-modified dsRNA-binding PNAs incorporating a fluorescent light-up uracil analog. Anal. Chem. 2019, 91, 5331-5338.

4.     Ong, A. A. L.; Toh, D. -F. K.; Krishna, M. S.; Patil, K. M.; Okamura, K.; Chen, G. Incorporating 2-thiouracil into short dsRNA-binding PNAs for enhanced recognition of A-U pairs and for targeting a microRNA hairpin precursor. Biochemistry 2019, 58, 3444-3453.

5.     Ong, A. A. L.; Toh, D. -F. K.; Patil, K. M.; Meng, Z.; Yuan, Z.; Krishna, M. S.;Devi, G.; Haruehanroengra, P.; Lu, Y.; Xia, K.; Okamura, K.; Sheng, J.; Chen, G. General recognition of U-G, U-A, and C-G pairs by double-stranded RNA-binding PNAs incorporated with an artificial nucleobase. Biochemistry2019, 58, 1319-1331.

6.     Kesy, J.; Patil, K. M.; Kumar, S. R.; Shu, Z.; .Yee, Y. H.; Zimmermann, L.; Ong, A. A. L.; Toh, D. -F. K.; Krishna, M. S.; Yang, L.; Decout, J.-L.; Luo, D.; Prabakaran, M.; Chen, G.; Kierzek, E. A Short Chemically-Modified dsRNA-Binding PNA (dbPNA) Inhibits Influenza Viral Replication by Targeting Viral RNA Panhandle Structure. Bioconjugate Chem.2019,30, 931-943.

7.     Patil, K. M.; Toh, D. -F. K.; Yuan, Z.; Meng, Z.; Shu, Z.; Zhang, H.; Ong, A. A. L.; Krishna, M. S.; Lu, L.; Lu, Y.; Chen, G. Incorporating uracil and 5-halouracils into short peptide nucleic acids for enhanced recognition of A-U pairs in dsRNAs.Nucleic Acids Res. 2018,46, 7506-7521.

8.     Puah, R. Y.; Jia, H.; Maraswami, M.; Toh, D. -F. K.; Ero, R.; Yang, L.; Patil, K. M.; Ong, A. A. L.; Krishna, M. S.; Sun, R.; Tong, C.; Huang, M.; Chen, X.; Loh, T. P.; Gao, Y. -G.; Liu, D. X.; Chen, G. Selective Binding to mRNA Duplex Regions by Chemically Modified Peptide Nucleic Acids Stimulates Ribosomal Frameshifting. Biochemistry2018, 57, 149-159.

9.     Bajpai, A.; Mukhopadhyay, A.; Krishna, M. S.; Govardhan, S.; Moorthy, J.N.  A fluorescent paramagnetic Mn metal–organic framework based on semi-rigid pyrene tetracarboxylic acid: sensing of solvent polarity and explosive nitroaromatics. IUCrJ2015,14,552-62.

10.   Moorthy, J. N.; Natarajan, P.; Krishna, M. S.; Nagarajaiaha, H.; Venugopalan, P. Isomorphous three-component crystals (pseudopolymorphs of binary cocrystals) based on lattice inclusion of guests with a sterically-rigidifiedtetraarylpyrene host. CrystEngComm2015,17, 5307-5314.

11.   Bajpai, A.; Krishna, M. S.;Moorthy, J. N. Engineering of Lattice Inclusion Based on Dimer Synthon-Mediated Hierarchical Self-Assembly of Carboxylic Acids. J. Ind. Inst. Sci.2014, 94, 25-34.

Conferences / Workshops / Seminars / FDP / Webinars – Attended

  1. Nov 2020 -  IQAC of RCASC organized FDP on “Influence of New Education Policy on quality parameter of Higher Education, Bengaluru, Karnataka, INDIA.
  2. Aug 2014  -  International Summer School on "Topological Methods for Expert Systems in Materials Science" at Samara State University, Samara, RUSSIA.
  3. Jul 2018 -    Developing Fluorescent Light-Up Probes for Detecting RNA Structures. Singapore RNA Biology Alliance Group Meeting, NUS, SINGAPORE
  4. Mar 2019 -    Developing Fluorescent Light-Up Probes for Detecting RNA Structures. Singapore-Paris Chemical Biology Workshop, NTU, SINGAPORE.
  5. Sep 2018  -  Developing Fluorescent Light-Up Probes for Detecting RNA Structures.      4th RNA Biology Symposium, NUS, SINGAPORE.
  6. Mar 2015 -   A Fluorescent Metal-Organic Framework Based on Pyrene-Tetra Carboxylic Acid: Solvatochromism and Sensing of Nitroaromatic Compounds. National Symposium on Radiation and Photochemistry (NSRP-2015), IIT Kanpur, INDIA

Membership in Professional Bodie

  • Member of Singapore National Institute of Chemistry (SNIC).

  • Member of Singapore RNA Biology.

  • Member of Graduate Alumni Association, Nanyang Technological University (NTU), Singapore.

  • Member of Alumni Association, Indian Institute of Technology, Kanpur (IIT-Kanpur).

  • Member: Association of Central College Chemistry Alumni, Central College Campus, Bengaluru.